Figure 4

Transcriptional immaturity of PFC in an animal model of schizophrenia. (a) Venn diagram illustrating the overlap in transcriptome-wide gene expression changes in the MFC of Shn-2 KO mice (Shn-2 KO compared to wild type) and that in human infants (GSE25219; infants, 1–5 years, compared with adults, 20–39 years). (b) P-values of overlap between Shn-2 KO mouse and human infant data sets. Bar graph illustrates the P-values of overlaps of genes upregulated (red arrows) or downregulated (blue arrows) by each condition, between the two conditions. The genes that showed the same directional changes in expression, or positive correlation, between two groups were designated Bioset4. (c–e) Comparison of gene expression derived from cell-type specific developmental experiments (c, FS neurons [GSE17806]; (d), astrocytes [GSE9566]; (e), oligodendrocytes [GSE9566]) with Bioset4. Bonferroni correction was used to adjust the significant level by the number of pairs of datasets included in each study (see the Methods section and Additional file1: Table S27). (f) Pie chart representing the percentage that a particular cell type contributes to the altered gene expression pattern in Bioset4.