Genes and signaling pathways involved in memory enhancement in mutant mice

Table 2 LTP enhancement without memory enhancement

Mutant	LTP phenotypes	Memory phenotypes	Reference
Psd-95 KO	Enhanced CA1 LTP	Impaired in MWM	[129]
Limk-1 KO	Enhanced CA1 LTP	Normal initial learning, impaired reversal learning in MWM	[134]
Syndecan-3 KO	Enhanced CA1 LTP	Impaired in MWM	[135]
PTPδ KO	Enhanced CA1 and CA3 LTP	Impaired in MWM, RAM	[136]
IRSp53 KO	Enhanced CA1 LTP	Impaired in MWM, ORT	[137]
G_iα1 KO	Enhanced CA1 LTP	Impaired in CFC, PA, ORT; but normal in MWM	[138]
Tropomodulin-2 KO	Enhanced CA1 LTP	Impaired in CFC, MWM	[139]
Dystrophin KO	Enhanced CA1 LTP	Impaired in MWM, ORT	[140]
Tsc2 KO	Enhanced CA1 LTP	Impaired in MWM, CFC^*	[114]
GluR2 (GluA2) KO	Enhanced CA1 LTP	Impaired in MWM	[141, 142]
Fmr2 KO	Enhanced CA1 LTP	Impaired in CFC, but normal in MWM	[133]
dnPAK Tg	Enhanced cortical LTP	Impaired in MWM (21 days), CFC (1 day)	[143]
Inositol 1,4,5-triphosphate 3-kinase KI	Enhanced CA1 LTP	No change in MWM	[144]

KO, knockout; Tg, transgenic; KI, knock-in; MWM, Morris water maze; RAM, radial arm maze; ORT, object recognition test; CFC, contextual fear conditioning; PA, passive avoidance; *impaired in contextual discrimination test.

ISSN: 1756-6606