Table 3 RNA editing of AMPA receptors in the postmortem brains of patients with mental disorders
From: A role of ADAR2 and RNA editing of glutamate receptors in mood disorders and schizophrenia
| Â | R/G sites | Â | Â | Â | Â | Â | Q/R sites |
|---|---|---|---|---|---|---|---|
| Â | GRIA2 flip | GRIA2 flop | GRIA3 flip | GRIA3 flop | GRIA4 flip | GRIA4 flop | GRIA2 |
Bipolar disorder | 64.4 ± 16.4 | 54.4 ± 12.5 | 66.3 ± 9.5 | 79.4 ± 10.6 | 56.0 ± 17.1 | 64.8 ± 15.8 | 96.6 ± 3.4 |
Depression | 62.5 ± 13.8 | 54.9 ± 5.3 | 61.9 ± 9.6 | 82.6 ± 7.7 | 55.0 ± 15.8 | 69.9 ± 10.7 | 97.6 ± 3.0 |
Schizophrenia | 66.0 ± 10.8 | 53.7 ± 8.0 | 66.0 ± 5.9 | 83.5 ± 9.4 | 60.5 ± 9.7 | 71.5 ± 6.1 | 99.0 ± 1.9 |
Control | 70.1 ± 4.8 | 58.1 ± 4.4 | 65.0 ± 12.1 | 85.5 ± 3.5 | 63.2 ± 9.5 | 71.2 ± 7.5 | 98.8 ± 2.3 |
r* (GAPDH) | 0.508 | 0.476 | 0.300 | 0.644 | 0.527 | 0.565 | ns |
r* (CFL1) | 0.477 | 0.430 | 0.251 | 0.642 | 0.509 | 0.600 | ns |