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Figure 3 | Molecular Brain

Figure 3

From: SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

Figure 3

Effects of SIRT1 overexpression on the lifespan and onset of non-transgenic, and high and low copy SOD1G93Atransgenic mice. ( A and B ) Survival (A) and the onset of the symptom, determined by weight reduction (B) of SOD1G93A-L (n = 19) and SOD1G93A-L/PrP-Sirt1 (n = 16) mouse cohort plotted over time. ( C and D ) Survival (C) and the onset of the symptom (D) of SOD1G93A-H (n = 21) and SOD1G93A-H/PrP-Sirt1 (n = 15) mouse cohort plotted over time. The data were analyzed by log-rank test and the average onset and survival time are shown with SD.

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