Figure 3
Effects of SIRT1 overexpression on the lifespan and onset of non-transgenic, and high and low copy SOD1G93Atransgenic mice. ( A and B ) Survival (A) and the onset of the symptom, determined by weight reduction (B) of SOD1G93A-L (n = 19) and SOD1G93A-L/PrP-Sirt1 (n = 16) mouse cohort plotted over time. ( C and D ) Survival (C) and the onset of the symptom (D) of SOD1G93A-H (n = 21) and SOD1G93A-H/PrP-Sirt1 (n = 15) mouse cohort plotted over time. The data were analyzed by log-rank test and the average onset and survival time are shown with SD.