Figure 6

Effects of MgT treatment on expression of NR2B and BACE1 in wild type mice. (A) Left: Representative Western blots of NR2B expression in the hippocampus of WT mice sacrificed under home-cage conditions (basal) or following 24 h of environmental enrichment-based stimulation (Stim.). Middle: Quantitative analysis of NR2B expression in the hippocampus of WT and WT + MgT mice (n = 5/group) obtained by Western blot (arbitrarily units, a.u.). Mice were sacrificed under basal conditions without behavioral stimulation. Right: Quantitative analysis of NR2B expression in the hippocampus of WT and WT + MgT mice (n = 6/group) obtained by Western blots following behavioral stimulation. (B) Left: Representative Western blots of BACE1 (β-secretase) expression in the hippocampus of WT mice sacrificed under home-cage conditions (basal) or following 24 h of environmental enrichment-based stimulation (Stim.). Middle: Quantitative analysis of BACE1 expression in the hippocampus of WT and WT + MgT mice (n = 5/group) obtained by Western blot (arbitrarily units, a.u.). Mice were sacrificed under basal conditions without behavioral stimulation. Right: Quantitative analysis of BACE1 expression in the hippocampus of WT and WT + MgT mice (n = 6/group) obtained by Western blots following behavioral stimulation. Two tailed unpaired t-test. Error bars show SEM. * p < 0.05.