Figure 6From: Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse modelEffects of MgT treatment on expression of NR2B and BACE1 in wild type mice. (A) Left: Representative Western blots of NR2B expression in the hippocampus of WT mice sacrificed under home-cage conditions (basal) or following 24 h of environmental enrichment-based stimulation (Stim.). Middle: Quantitative analysis of NR2B expression in the hippocampus of WT and WT + MgT mice (n = 5/group) obtained by Western blot (arbitrarily units, a.u.). Mice were sacrificed under basal conditions without behavioral stimulation. Right: Quantitative analysis of NR2B expression in the hippocampus of WT and WT + MgT mice (n = 6/group) obtained by Western blots following behavioral stimulation. (B) Left: Representative Western blots of BACE1 (β-secretase) expression in the hippocampus of WT mice sacrificed under home-cage conditions (basal) or following 24 h of environmental enrichment-based stimulation (Stim.). Middle: Quantitative analysis of BACE1 expression in the hippocampus of WT and WT + MgT mice (n = 5/group) obtained by Western blot (arbitrarily units, a.u.). Mice were sacrificed under basal conditions without behavioral stimulation. Right: Quantitative analysis of BACE1 expression in the hippocampus of WT and WT + MgT mice (n = 6/group) obtained by Western blots following behavioral stimulation. Two tailed unpaired t-test. Error bars show SEM. * p < 0.05.Back to article page