Figure 7
From: Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference
MP-10 (10.0 mg/kg) causes long-lasting changes in expression of ΔFosB immunoreactivity. (A) Immunofluorescence images of ΔFosB in different brain areas from rats that received saline (Sal, 2 ml/kg, s.c.), morphine (Mor, 10 mg/kg, s.c.), MP-10 (MP-10, 10.0 mg/kg, s.c.) or combination of both MP-10/Mor, (MP-10 was administration 30 min prior to morphine) after CPP testing (scale bar, 50 μm). (B) Quantification of ΔFosB-positive nuclei. Data are expressed as mean±SEM and analyzed by two-way ANOVA followed by Bonferroni posttests. *P < 0.05, **P < 0.01, when compared with saline group. N = 5 per group. DMS: dorsomedial striatum; SHELL: NAc shell; ACC: anterior cingulate cortex.