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Figure 5 | Molecular Brain

Figure 5

From: Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats

Figure 5

Increase in amplitude of membrane oscillation in CeA neurons in SNL-induced anxiety rats. (A): representative of three different firing patterns and membrane oscillation of CeA neurons recorded in spontaneous discharges mode under whole-cell current-clamp recording. Lower panel in each firing pattern: enlarged trace shows that membrane oscillation emerges in silent, multispike and burst firing neurons in na''ve rats. (B): representative multispike firing pattern recorded from CeA neurons in na''ve, sham and SNL rats. Lower panel in each group: enlarged trace showing enhanced membrane potential oscillation in SNL rats compared to na''ve and sham rats. (C): summary of the amplitude and frequency of membrane oscillation in CeA neurons in na''ve, sham and SNL rats. Note that although no difference was found in amplitude of basal oscillation among three groups (upper), the amplitude (middle) but not the frequency (lower) of main oscillation is increased dramatically in SNL rats compared to na''ve and sham rats. *p < 0.05, **p < 0.01, one-way ANOVA, n = 12 - 15/group. All recorded cells in each group are obtained from animals of na''ve (4 rats); sham (4 rats) and SNL (6 rats), respectively.

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Molecular Brain

ISSN: 1756-6606