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Figure 9 | Molecular Brain

Figure 9

From: The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release

Figure 9

Diagram of proposed mechanism mediating activity-dependent regulatory function of nPKCε on ACh release linked to muscle contraction. The diagram illustrates how synaptic activity induced-muscle contraction could regulate the presynaptic action of the nPKCε through TrkB signalling in the neurotransmission release. The activity of the nPKCε isoform requires muscle cells to contract if the presynaptic membrane level of nPKCε is to be maintained or increased (probably with the involvement of the stabilizing action of HSP70). Finally, we hypothesize that nPKCε is functionally related in the neurotransmission mechanism on the NMJs.

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Molecular Brain

ISSN: 1756-6606