Figure 3From: Dexmedetomidine inhibits Tetrodotoxin-resistant Nav1.8 sodium channel activity through Gi/o-dependent pathway in rat dorsal root ganglion neurons Effect of DEX on the steady-state activation and inactivation curves of Na v 1.8. (A) DEX (3 μM) did not shift voltage-dependent activation curve. (B) DEX (3 μM) shifted the steady-state inactivation curve in a hyperpolarizing direction.Back to article page