mGluR5 function as scaffolds for the formation of A
oligomer and PrP
signaling complexes. The extracellular domain of mGluR5 interacts with both PrPc and Aβ42 which results in the activation of Ca2+ release from intracellular stores, PKC translocation and ERK1/2 phosphorylation. Aβ42 and PrPc also activate mGluR5 to stimulate Fyn kinase-mediated and mGluR5 activation has been linked to the regulation of APP protein translation. APP, amyloid precursor protein; DAG, diacylglycerol; ER, endoplasmic reticulum; ERK, extracellular regulated kinase; PLCβ, phospholipase Cβ; PrPc, cellular prion protein.