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Figure 1 | Molecular Brain

Figure 1

From: Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes

Figure 1

mGluR5 function as scaffolds for the formation of A β oligomer and PrP C signaling complexes. The extracellular domain of mGluR5 interacts with both PrPc and Aβ42 which results in the activation of Ca2+ release from intracellular stores, PKC translocation and ERK1/2 phosphorylation. Aβ42 and PrPc also activate mGluR5 to stimulate Fyn kinase-mediated and mGluR5 activation has been linked to the regulation of APP protein translation. APP, amyloid precursor protein; DAG, diacylglycerol; ER, endoplasmic reticulum; ERK, extracellular regulated kinase; PLCβ, phospholipase Cβ; PrPc, cellular prion protein.

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Molecular Brain

ISSN: 1756-6606