Figure 4

Six month old Aldh2 ^-/- mice exhibit decreased performance in the Morris Water Maze task. (A). Escape latency (time to reach the hidden platform) was determined in a 3 day cued trial block (4 trials per day) followed by a 5 day hidden trial block (6 trials per day). Day 9 was a probe trial, in which the time spent in the target quadrant (NE)(B) and number of platform crosses (C) were determined (total time of the trial was 60 s). In (A), data are expressed as the mean ± SD of the average scores in each trial block (n = 18). In B and C, data are expressed as the mean ± SD (n = 18). In B, the dotted line represents the expected time spent in each quadrant by chance alone. Data were analyzed by 2-way ANOVA with a Bonferroni post-hoc test in A and B, and by a Student’s t-test for unpaired data in C. In A and C, *, significant difference from wildtype as indicated (*p < 0.05, ** p < 0.01, ***p < 0.001). In B, ***, significant difference from wildtype in the other quadrants; (p < 0.001); ^ψψψ, significant difference from Aldh2 ^-/- in the NE quadrant (p < 0.001).