Fig. 2

Spatial reference learning and memory impairment observed in cisplatin-treated rats exposed to the water maze test. a - b In the probe training sessions, the acquisition curve of cisplatin rats was impaired compared with control rats. c - d In 60 s probe tests, cisplatin-treated rats spent significantly lower percentage of time in the quadrant previously containing the platform than control rats, suggesting impaired memory. An asterisk indicates levels of significance for the difference between controls and cisplatin-treated rats.* p < 0.05, ** p < 0.01