Fig. 6

Cisplatin disrupted the spikes phase-locking in the ACC. a Test of significance of phase-locking as a function of frequency (1 – 64 Hz). The threshold (red line) for significant phase-locking was set to p = 0.0023 (0.05/22, Bonferroni corrected). The shown phase-locked neuron in the control rat (gray line) exhibited maximal phase-locking at 9.5 Hz while the un-phase-locked neuron in the cisplatin-treated rat (black line) showed no significant phase-locking in theta range. b Histogram of the preferred phase of all phase-locked neurons in the control rats (n = 53 of 120). The figure shows most phase-locked neurons preferred to fire during the descending phase or at the trough of the oscillation. The red line is a schematic of the theta cycle. c The polar-histogram of the spike-field phase distribution of the phase-locked neuron from the control rat shown in (A). The figure shows the majority of spikes of this neuron fired close to 180°. The mean phase shown by the red arrows indicates this neuron preferred firing at 184° of the theta oscillation. The vector length R = 0.23. d Polar-histogram of the spike-field phase distribution of the un-locked neuron from the cisplatin-treated rat shown in (A). The figure shows this neurons action potential firing at random angles of the theta cycle oscillations suggesting disrupted phase-locking in rats following cisplatin treatment. The vector length R = 0.03