Fig. 3

NMDA receptor-mediated long-term depression and depotentiation in wild-type and cAMP-GEF II ^−/− mice. a, Long-term depression (LTD) induced by low frequency stimulation (1x LFS; 1 Hz for 15 min) was impaired in cAMP-GEF II ^−/− (KO) mice. b, There was a significant difference in NMDA receptor-LTD between wild-type and cAMP-GEF II ^−/− mice during the last 5 min of recording (WT = 75.54 ± 4.27 %, 11 slices from eight mice; KO = 90.74 ± 4.5 %, 9 slices from eight mice; unpaired t-test, p < 0.03). c, Depotentiation in wild-type (WT = 131.55 ± 8.3 %, 8 slices from four mice) and cAMP-GEF II ^−/− mice (KO = 121.69 ± 9.7 %, 8 slices from four mice; arrow, three trains of theta-burst stimulation). d, There was no difference in depotentiation between wild-type and cAMP-GEF II ^−/− mice during the last 5 min of recording. Abbreviations: fEPSP, field excitatory postsynaptic potential. NS, no significance