Fig. 4

Foot shock sensitivity test in 12-month-old male mice. KO mice showed significantly less sensitivity to foot shock stimuli (12-month-old male mice; n = 14 mice per genotype; Two-way ANOVA; F_{(1, 83)} = 27.03, *p < 0.0001 for genotype; F_(2,83) = 64.0, p < 0.00001 for behavior; F_(2,83) = 1.14, p = 0.32 for genotype and behavior). Data are shown as mean ± SEM