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Fig. 5 | Molecular Brain

Fig. 5

From: Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins

Fig. 5

PIWIL1 affects neuronal migration through regulating the expression of MAPs. a, b MAP2 levels (bands indicated by the arrow) were significantly decreased in the cortical tissue of adult PIWIL1-knockout mice (tissues were all from male animals). Statistics analysis was based on 4 technical repeats on pooled samples (n = 2). c Cortex of PIWIL1-knockout mice showed lower level of MAP2 immunofluorescence signal (red arrows indicate MAP2 signal in WT brain). Scale bar, 20 μm. d, e Co-electroporation of MAP2B with PIWIL1 siRNA largely attenuated the migration defect in mouse brains. Scramble vs RNAi 2; RNAi 2 + CAG vs RNAi 2 + MAP2B. Scale bar, 150 μm. Error bar, SEM, *P < 0.05, **P < 0.01, ***P < 0.001 (Student’s t-test)

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Molecular Brain

ISSN: 1756-6606