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Fig. 5 | Molecular Brain

Fig. 5

From: Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice

Fig. 5

Effects of m-PFC microinjection of PEA or OEA (6 nmol/mouse) or vehicle (DMSO/ACSF, 0.05 %, v/v) on mechanical allodynia (a) in SNI mice 30 days after surgery. Each point represents the mean ± standard error of the mean (S.E.M) of 6–7 mice. Black arrows indicates drug injection. * and ° indicate significant differences of PEA or OEA treatment, respectively compared to SNI/vehicle. P < 0.05 was considered statistically significant. “b”, “c” and “d” show the protein expression of mGluR5, Nr2a and Nr2b, respectively, normalized to β-Tubulin. Data are represented as a mean ± SEM of 4–5 samples per group. * indicates significant differences compared to no treated cells. P < 0.05 was considered statistically significant. ANOVA, post hoc Tukey

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Molecular Brain

ISSN: 1756-6606