Fig. 4
From: Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity
Effect of BQ788 and Cav-1 peptide on SE-induced LIMK2 expression at 3 days after SE. a Western blot image of LIMK2 in the hippocampus. BQ-788 infusion attenuates up-regulation of LIMK2 expression induced by SE, while Cav-1 peptide does not. b Quantitative values (mean ± S.E.M) of LIMK2 mRNA/protein expression level in the hippocampus (n = 10 per each group). Significant differences from vehicle, *p < 0.05. c-f Representative photographs of LIMK2 and NeuN in the CA1 pyramidal cells. As compared to vehicle, BQ788 inhibits LIMK2 induction following SE. Bar = 50 μm. g Quantitative values (mean ± S.E.M) of LIMK2 and NeuN in the hippocampus (n = 10 per each group). Significant differences from vehicle, *p < 0.05