Table 1 Major substrates of SCF ubiquitin ligases, Fbw7, β-TrCP, and SKP2

SCF-Fbw7

  Notch

Cell proliferation signaling

[140–143]

  c-Myc

Transcription factor

[140, 144, 145]

  c-Jun

Kinase

[146]

  Cyclin E

Cell cycle regulator

[26, 147]

  Mcl-1

Differentiation protein

[148]

  SREBP

Transcription factor

[149]

  PGC-1a

Transcription factor involved in energy metabolism

[150]

  Nrf-1

Transcription factor

[151]

  TGIF

Transcriptional repressor of TGF-b

[152]

  Aurora-A

Kinase and regulator of chromosome segregation

[153, 154]

  SV40 T antigen

Viral oncogene

[155]

  KLF5

Transcription factor

[156]

  mTor

Kinase

[157]

SCF-βTrCP

  Gli2

Transcription factor

[158, 159]

  GLi3

Transcription factor and mediator of SHH signaling

[160, 161]

  B-catenin

Transcription factor and cell adhesion; mediator of Wnt signaling

[162–164]

  IkBα

NFkB inhibitor

[163–166]

  mdm2

Ubiquitin ligase for p53

[148]

  Wee1

Cell cycle regulator kinase

  Cdc25a

Phosphatase in cell cycle regulation

[167]

  Rest

Gene suppressor and chromosome stabilizer

[133]

  Nrf-2

Transcription factor for antioxidant enzymes

[168]

  Emi1

Cell cycle regulator kinase

[167]

  HIV-1 Vpu

Viral pseudosubstrate

[169]

  Per1/2

Circadian regulation

[170–172]

  Snail

Neural crest regulation

[173]

  DEPTOR

Autophagy inhibitor

[174]

  Mcl-1

Differentiation protein

[175]

SCF-SKP2

  p27

Cell cycle regulator

[176, 177]

  p21

Cell cycle regulator

[178, 179]

  E2F

Transcription factor

[180]

  Akt

Protein kinase

[181]

  FOX01

Transcription factor

[182]

  Brca2

DNA repair

[183]

  cyclin A

Cell cycle regulator

[184]

  cyclin E

Cell cycle regulator

[185]

  c-myc

Transcription factor

[186]

  HPV Viral E7

Viral oncogene

[187]