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Table 1 Major substrates of SCF ubiquitin ligases, Fbw7, β-TrCP, and SKP2

From: The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma

SCF-Fbw7   
  Notch Cell proliferation signaling [140143]
  c-Myc Transcription factor [140, 144, 145]
  c-Jun Kinase [146]
  Cyclin E Cell cycle regulator [26, 147]
  Mcl-1 Differentiation protein [148]
  SREBP Transcription factor [149]
  PGC-1a Transcription factor involved in energy metabolism [150]
  Nrf-1 Transcription factor [151]
  TGIF Transcriptional repressor of TGF-b [152]
  Aurora-A Kinase and regulator of chromosome segregation [153, 154]
  SV40 T antigen Viral oncogene [155]
  KLF5 Transcription factor [156]
  mTor Kinase [157]
SCF-βTrCP   
  Gli2 Transcription factor [158, 159]
  GLi3 Transcription factor and mediator of SHH signaling [160, 161]
  B-catenin Transcription factor and cell adhesion; mediator of Wnt signaling [162164]
  IkBα NFkB inhibitor [163166]
  mdm2 Ubiquitin ligase for p53 [148]
  Wee1 Cell cycle regulator kinase  
  Cdc25a Phosphatase in cell cycle regulation [167]
  Rest Gene suppressor and chromosome stabilizer [133]
  Nrf-2 Transcription factor for antioxidant enzymes [168]
  Emi1 Cell cycle regulator kinase [167]
  HIV-1 Vpu Viral pseudosubstrate [169]
  Per1/2 Circadian regulation [170172]
  Snail Neural crest regulation [173]
  DEPTOR Autophagy inhibitor [174]
  Mcl-1 Differentiation protein [175]
SCF-SKP2   
  p27 Cell cycle regulator [176, 177]
  p21 Cell cycle regulator [178, 179]
  E2F Transcription factor [180]
  Akt Protein kinase [181]
  FOX01 Transcription factor [182]
  Brca2 DNA repair [183]
  cyclin A Cell cycle regulator [184]
  cyclin E Cell cycle regulator [185]
  c-myc Transcription factor [186]
  HPV Viral E7 Viral oncogene [187]