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Fig. 4 | Molecular Brain

Fig. 4

From: Long-term upregulation of cortical glutamatergic AMPA receptors in a mouse model of chronic visceral pain

Fig. 4

The effect of AMPA inhibitor IEM1460 on behavioral test in the animal model of IBS. a The time course of cannulation surgery, zymosan injection, microinjection, and behavioral tests. b Schematic showing cannula tip placements in the ACC. C-H) The mice injected with zymosan exhibited obvious visceral pain behavior (c), the decreased travel distance (d), vertical counts (e), ambulatory counts (f), stereotypic counts (g), and jump counts (h) in open field test. However, the microinjection with IEM 1460 totally blocked the effects of zymosan in mice. IEM 1460 had no effect in control mice. N = 6 mice per group, ** P < 0.01 vs. control (No cannula), # P < 0.05, ## P < 0.01 vs. zymosan + IEM 1460

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Molecular Brain

ISSN: 1756-6606