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Fig. 2 | Molecular Brain

Fig. 2

From: Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

Fig. 2

PV immunofluorescence images from mPFC of a PV+/- (a), SSC of a Shank1-/- (b) and striatum of a Shank3B-/- (c) mouse in comparison to the same regions of a WT mouse. PV expression levels (≈ signal intensity) varied considerably between individual PV+ neurons. Note the generally weaker somatic staining in the mutant mice (right panels), also evident by the fainter staining of the PV-ir neuropil. The weaker staining results in a lower number of neurons considered as positive for PV as shown in Figs. 3, 4 & 6. Scale bars: 100 μm in a, c; 200 μm in b

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Molecular Brain

ISSN: 1756-6606