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Fig. 6 | Molecular Brain

Fig. 6

From: Endothelial progenitor cells and neural progenitor cells synergistically protect cerebral endothelial cells from Hypoxia/reoxygenation-induced injury via activating the PI3K/Akt pathway

Fig. 6

Co-culture with EPCs and NPCs activated the PI3K/Akt signal pathway on H/R-injured ECs. a, VEGFR2 expression was significantly upregulated in H/R-injured ECs co-cultured with NPCs or the combination of EPCs and NPCs. b the protein expression ratio of p-Flk1/VEGFR2 was significantly increased in H/R-injured ECs co-cultured with EPCs or NPCs, with a higher ratio in ECs co-cultured with the combination of EPCs and NPCs. c the protein expression ratio of p-Akt/Akt was increased in H/R-injured ECs co-cultured with EPCs and NPCs, and this effect was blocked or reduced when ECs were pre-treated with PI3K inhibitor LY294002 or VEGFR2 inhibitor SU1498 or TrkB inhibitor K252a. *p < 0.05, vs. Normoxia; #p < 0.05, vs. vehicle. Data are expressed as mean ± SEM, n = 6/group/measurement

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Molecular Brain

ISSN: 1756-6606