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Fig. 9 | Molecular Brain

Fig. 9

From: Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex

Fig. 9

BDNF and proBDNF modulate persistent activity by regulating presynaptic glutamate release in layer V of the entorhinal cortex. BDNF increases glutamate release via presynaptic TrkB activation whereas proBDNF inhibits glutamate release via presynaptic p75NTR receptors. Glutamate acts through postsynaptic Gq-coupled mGluR5 receptors, in addition to acetylcholine acting through M1 muscarinic receptors, to induce calcium entry through TRPC channels and initiation of persistent activity

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Molecular Brain

ISSN: 1756-6606