Fig. 5

Heatmap showing ratios of protein enrichment/depletion in the mitochondrial proteome of male and female AD + CVD subjects compared to age-matched controls. Log ratios in AD + CVD subjcets were normalized to controls (controls ratio = 1). Red values represent protein enrichment, blue values represent protein depletion and white values indicate no change in the ratio scale. Protein names were listed on the right side of each heat map line. All proteins reported here are significantly modified versus controls (p < 0.05). Significance level between AD + CVD groups (* p < 0.05 and gender difference ≥ 0.2). Tabular data of values shown in this heat map can be found in Additional file 2: Table S2