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Fig. 6 | Molecular Brain

Fig. 6

From: Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/β-catenin signaling in the hypothalamus

Fig. 6

Wnt3a upregulates NeuroD1 and Ins2 in the mouse hypothalamus. The basal mRNA levels of Ins2 and Wnt3a were measured by qRT-PCR in hypothalamic tissues from C57BL/6 male mice (n = 6−9) (a). C57BL/6 male mice received icv injections of vehicle or Wnt3a (4 or 20 ng), and hypothalamic tissues were dissected after 24 h. The mRNA levels of Ins2 (b) and NeuroD1 (c) were measured by qRT-PCR (n = 6−9). Data are means + SEM. ###p < 0.001 compared with Ins2 mRNA, ***p < 0.001 compared with vehicle administration

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Molecular Brain

ISSN: 1756-6606