Fig. 2

Blocking or promoting Mdm2-p53 signaling does not affect neural network bursting activity before or after neuronal activity stimulation. a Representative traces of bursting activity from cultures treated with various agents as indicated. Traces are from a designated electrode before and after treatment. b Quantification of the number of spikes per burst after treatment. Plotted is the average of “after treatment” normalized to the mean of its own “before treatment” for each MEA. ANOVA with post-hoc Tukey test was used. (n = 5–8 cultures, *p < 0.05, ***p < 0.001)