Fig. 2
From: Linking F-box protein 7 and parkin to neuronal degeneration in Parkinson’s disease (PD)
Physiological roles of FBXO7 and Parkin in UPS. a, the physiological roles of FBXO7 in SCFFBXO7 E3 ligase complex. FBXO7 acts as an adaptor protein to recognize and interact with its substrates for SCFFBXO7 E3 ligase mediated ubiquitination. After interaction with its substrates, FBXO7 will bind with SKP1 which further interact with Cul1 and ROC1 to form functional SCFFBXO7 E3 ligase complex. The SCFFBXO7 E3 ligase will mediate E2 ligase induced ubiquitination of FBXO7 substrates. b, the physiological roles of Parkin. After interaction with its substrates, Parkin exerts its E3 ligase activity to mediate ubiquitination of its substrates by E2 ligase. c, detailed procedures of SCFFBXO7 and Parkin E3 ligases mediated ubiquitination and proteasome degradation of substrates. (Left), SCFFBXO7 E3 ligase mediated substrates recognition, ubiquitination and proteasomal degradation. (Right), Parkin mediated substrates recognition, ubiquitination and proteasomal degradation