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Fig. 1 | Molecular Brain

Fig. 1

From: Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice

Fig. 1

Simplified scheme of the imprinted Gnas locus. The Gnas and Gnasxl transcripts, which encode the Gαs and XLαs proteins, respectively, are shown with their alternative promoters and splicing arrangements. Promoter activities on the two parental alleles are indicated by arrows. Gnasxl expression is suppressed by DNA methylation (MMM) on the maternal allele. Gnas is biallelelically expressed in most tissues, but silenced on the paternal allele is some cell types (hatched box and arrow). For simplicity, other features of the locus, e.g. non-coding RNAs, are not shown

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Molecular Brain

ISSN: 1756-6606