Fig. 5
From: Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1
NMDAs R regulate the increase in sEPSC following PIH application. a. Adding AP5 to the bath after PIH application causes sEPSC frequency to return to baseline. This shows snap shots of whole cell recordings during initial control (no drug), PIH application, and then AP5 in addition to 100 μM PIH (n = 5). b. Quantification of sEPSC frequency during PIH and PIH with AP5 normalized to control frequency before any drug application. There is a decrease in EPSC frequency back to baseline after AP5 is added to the bath (n = 5 *p < 0.05