Fig. 3
From: Altered DNA base excision repair profile in brain tissue and blood in Alzheimer’s disease
Relative mRNA levels of OGG1, PARP1 and Polβ in selected diagnostic groups (mean ± 2 SEM) in AD patients with dementia, mild cognitive impairment (MCI) due to AD (MCI/AD), MCI, subjective cognitive impairment (SCI) and healthy controls (HC). p-values: * < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001. a The box plot show that the mRNA levels of OGG1 are significantly lower in the diagnosis groups: MCI (p <0.01), MCI/AD (p <0.05) and AD dementia (p <0.05) compared to HC. b The box plot show that the mRNA levels of PARP1 are significantly higher in the diagnosis groups: SCI (p <0.0001), MCI (p <0.01), MCI/AD (p <0.001) and AD dementia (p <0.05) compared to HC. c The box plot show that the mRNA levels of Polβ are significantly higher in the diagnosis group AD dementia (p <0.05) compared to HC