Fig. 3
APLP2-KO mice have a nonprogressive defect in retinal responses postsynaptic to rod photoreceptors and cone circuitry function. Representative voltage traces from flash ERG recording in young (a) and adult (b) dark-adapted WT (left column) and APLP2-KO (right column) mice. Numbers on left of the traces correspond to the luminances (log cd.s.m−2) of the flashes that elicit these responses. The scale indicates 150 ms and 500 μV. c Examples of comparisons of responses obtained from WT and APLP2-KO mice are illustrated by superimposing the respective traces obtained from these two mouse genotypes. Responses to low-intensity stimuli (−1.9 log cd.s.m−2 under dark adaptation) and responses to high-stimuli (0.46 log cd.s.m−2 under dark adaptation). d Amplitude of the cone ERG b-wave in young (scare symbol) and adult (round symbol) APLP2-KO (white symbols) and WT (black symbols). e Maximal b-wave amplitude (B max ) in young and adult APLP2-KO (white bars) and WT (black bars). Means ± s.e.m., N = 6 mice per genotype. N = 6 mice per age group. *, p < 0.05. (t-test)