Fig. 8From: Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junctionInvolvement of the AR and TrkB receptors in the morphological maturation of the postsynaptic apparatus. The figure shows the percentage of the MS1-MS4 clusters in the NMJ of the untreated YFP control mice (exposed to PBS), and after 2 (P7 in a), 4 (P9, in b) and in some cases 10 (P15, in c) applications (one application every day after P5) of the TrkB blocking chimera TrkB-Fc, the AR pan-inhibitor 8SPT and the AR agonist ADO. We also studied axonal elimination after selectively blocking A1R with DPCPX and inhibiting A2AR with SCH-58261. Fisher’s test: * p < 0,05, ** p < 0,01, *** p < 0,005Back to article page