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Fig. 8 | Molecular Brain

Fig. 8

From: Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction

Fig. 8

Involvement of the AR and TrkB receptors in the morphological maturation of the postsynaptic apparatus. The figure shows the percentage of the MS1-MS4 clusters in the NMJ of the untreated YFP control mice (exposed to PBS), and after 2 (P7 in a), 4 (P9, in b) and in some cases 10 (P15, in c) applications (one application every day after P5) of the TrkB blocking chimera TrkB-Fc, the AR pan-inhibitor 8SPT and the AR agonist ADO. We also studied axonal elimination after selectively blocking A1R with DPCPX and inhibiting A2AR with SCH-58261. Fisher’s test: * p < 0,05, ** p < 0,01, *** p < 0,005

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