Fig. 4
CD mice exhibit normal LTP induction mechanisms. a Waveforms of the postsynaptic responses generated by the 1st and 2nd theta burst in the first train of the TBS protocol. Note that the second burst response in each case is larger than the first and does not return as quickly to baseline. Comparison of the averaged composite fEPSPs recorded from WT and CD slices indicates that the mutation does not affect the waveform of the response or its transformation within the train. b Mean sizes of initial burst responses in each train was similar in WT and CD mice (p = 0.96, two-way repeated measures ANOVA). c Facilitation of burst responses was calculated by expressing the area of the composite fEPSP corresponding to the 2nd theta burst within each train as a fraction of the 1st burst response. Two-way repeated measures ANOVA revealed no differences between genotypes (p = 0.30). WT: n = 12, CD: n = 16. Data are presented as the mean ± SEM