Fig. 5

Effect of HDAC6 or Drp1 inhibition on Aβ–O induced mitochondria trafficking impairment and fragmentation. a Quantitative analysis showing the changes in moving mitochondria after 30 min exposure to different HDAC inhibitors (TSA 10 μM, tubacin 20 μM, MS-275 5 μM) or Drp1 inhibitor (Mdivi-1 20 μM) with and without Aβ–O. b Representative images showing the morphology of mitochondria before and after 2 h exposure to control or Aβ-O (5 μM total) without or with presence of TSA or Mdivi-1. Scale bar: 5 μm. c Bar graph showing the changes in the average mitochondrial length and total number in response to Aβ–O without and with HDAC6 or Drp1 inhibitions in bath. Numbers represent the number of dishes examined with a total of 10–20 cells for each data point. Error bars indicate SD. *p < 0.05 and **p < 0.005 in comparison to the corresponding control (Student’s t test)