Fig. 4

5b (novel blocker of ASICs) has little effect on inward GABAergic currents in ‘HEPES 10’ solution. In the same series of experiments during each sweep evoked PSCs were recorded below their reversal potential as inward currents (a), and above the reversal potential, as outward ones (b). Superimposed traces of original current traces (averages of 10 sequential PSCs) before (solid lines) and after (dotted lines) 5b (1 μM) application are shown on the right panel, summary graphs (n = 5) are shown on the left panel. PSC-amplitudes were normalized to control values (average of 20 PSCs preceding drug application). In control, absolute amplitudes of inward and outward currents (mean ± S.D) in this series of experiments were: -196.3 ± 92.6 pA; 193.1 ± 119.6 pA