Fig. 1From: Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profilingTau oligomer turnover and principal clearance mechanisms. Impairment of one or both clearance pathways leads to protein accumulation and toxicity which impairs cellular function and eventually induces cell death. (Adapted from Cárdenas-Aguayo et al. [11])Back to article page