Fig. 4

Heantos does not affect burst firing in TRN neurons.  a Representative voltage traces showing input-output response of the same TRN thalamic neuron before (left) and after (right) application of Heantos (1 mg/ml, 5 mg/ml). Lower panels show current injection protocol. Black traces show the threshold burst voltage and corresponding current injection. The same voltage traces are displayed at a higher time resolution of the region delineated by grey box for clarity. b Histograms summarizing mean current injection for burst threshold, c resting membrane potential, d number of action potentials and e mean input resistance for TRN thalamic neurons before and after a 5 min application of Heantos (1 mg/ml (n = 5), 5 mg/ml (n = 3))