Fig. 3

N-terminus deletion mutant APE1/Ref-1 (ΔNLS-Ref-1) inhibits LPS-induced iNOS expression and TNF-α secretion in astrocytes. a Western blot analysis showing the effects of ΔNLS-Ref-1 expression by plasmid transfection on LPS-induced iNOS expression. b Summarized data showing the ΔNLS-Ref-1 inhibition of LPS-induced iNOS expression, as in A. Data represent the mean ± SEM (n = 4). c Effects of wild-type (WT-Ref-1) and ΔNLS-Ref-1 overexpression on LPS-induced TNF-α secretion from astrocytes. Data represent the mean ± SEM of three separate experiments. ** p < 0.01 vs. non-transfected control cells