Fig. 1
From: ApoE isoforms differentially regulates cleavage and secretion of BDNF
Human Alzheimer’s disease hippocampus has lower BDNF levels. a Immunoblot showing BDNF expression in the hippocampus of four AD and four age matched controls (AC). In AD hippocampus the prepro-BDNF levels were significantly lower than AC hippocampus (AC: 1.8 ± 0.14, n = 7; AD: 1.25 ± 0.11, n = 6. P = 0.012) b and negatively correlated with the Braak stage c. Pro-BDNF expression were also lower in AD hippocampus (AC: 0.81 ± 0.07, n = 7; AD: 0.49 ± 0.073, n = 6. P = 0.0073) d, e. Data are represented as mean ± SE (Student’s t-test, *P < 0.05 and **P < 0.005)