Fig. 8
Effect of 5-HT on mEPSC in the presence of NAN-190. a Representative mEPSC traces recorded in the presence of NAN-190 (5 μM). b Cumulative probability plots showing the distribution of mEPSC amplitude (left) and interval-events interval (right). Black line represented the phase of baseline and dashed green line represented the phase of 5-HT application. c Summary plots of mEPSC data. Averaged values of mEPSC parameters: mean amplitude (left) and peak frequency (right) (n = 8 neurons/6 mice). In the presence of NAN-190, one antagonist of 5-HT1A receptor, both the frequency and amplitude did not change evidently after bath application of 5-HT