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Fig. 8 | Molecular Brain

Fig. 8

From: Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice

Fig. 8

Seizure-like activity was suppressed by light stimulation in the nRT in freely moving mice. a The left column shows spontaneous field potentials in the S1 region based on EEG recordings. The right column shows spontaneous field potentials after STFT. b Seizure-like activity was induced by PTZ (50 mg/kg, i.p.). The right column shows the field potentials of seizure-like activity. c The left column showed EEG waves in the S1 region in seizure onset period. Blue marks represent the light stimulation periods in the nRT. Seizure like activities were suppressed when light stimulation turned on. Right column presented STFT in seizure-like activities and seizure suppression period. d Different light stimulation conditions in the pre- and post-seizure periods. FFT power was analyzed and divided into three frequency bands (theta, 4–7 Hz; alpha, 8–15 Hz; beta, 16–30 Hz). In the post-seizure periods, the frequency power significantly decreased in all three bands when 10 and 100 Hz light stimulation was applied. *p < 0.05 compared with different light stimulation, ## p < 0.05 compared with control and seizure groups. Error bars indicate SEM. (one-way ANOVA with repeated test followed by post hoc test)

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