Fig. 1

Pretreatment of TsI rescues the deficits of myodynamia and motor functions in neonatal HIBD rats. a The flowchart illustrates the experimental protocols of TsI treatments and behavioral tests. Rats received TsI treatment (5 mg/kg per day, i.p.) twice before and five times after HIBD model establish, and the second treatment of TsI was 6 h before the surgery. Two days after HIBD, brain tissue was collected for oxidative stress analysis. Grasping test and rotarod test were performed on postnatal day 28 and 29 (P28–29), and the Morris water maze test was performed from postnatal day 35 to 42 (P35–42). After behavioral tests, brain tissues were collected for immunohistochemistry. b The left and right forelimb myodynamia during the grasping test. c The latency to fall off the rod during the rotarod test. The data was presented as mean ± SEM. *p < 0.05