Fig. 2
From: Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition
Inhibition of PKR restores LTP impairment in 5XFAD mice. a LTP in Schaffer-collateral-CA1 pathway was induced by theta burst stimulation (TBS). Field excitatory synaptic potential (fEPSP) slopes were normalized by the average of baseline recordings. Slices from 5XFAD mice showed significantly reduced LTP than WT, which can be restored by PKRi treatment (1 μM, 90 min). Representative traces were shown above. Black, baseline; Green, average between 40 and 50 min after TBS. Vertical bar, 1.0 mV; horizontal bar, 5 ms. b Cumulative data showing the average field excitatory synaptic potential (fEPSP) slope of 40–50 min after TBS (WT, 147.77 ± 2.19%, n = 6 slices from 4 mice; WT + PKRi, 142.83 ± 3.10%, n = 9 slices from 5 mice; 5XFAD, 126.22 ± 2.36%, n = 7 slices from 5 mice; 5XFAD and PKRi, 151.67 ± 11.20%, n = 5 slices from 3 mice; Two-way ANOVA, interaction between genotype and PKRi, *p < 0.05, Two-way ANOVA, Bonferroni post-tests, **p < 0.01). Bars represent as mean ± SEM