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Fig. 1 | Molecular Brain

Fig. 1

From: Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory

Fig. 1

Inhibition of hippocampal calpain blocks the consolidation of contextual fear memory. a and b Effects of a microinfusion of a low-, middle-, or high-dose of N-Acetyl-Leu-Leu-norleucinal (ALLN) into the dorsal hippocampus immediately after the training on LTM in female (a) or male (b) mice (a: VEH, n = 28; ALLN 0.2 μg, n = 14; ALLN 1 μg, n = 10; ALLN 2 μg, n = 25; b: VEH, n = 14; ALLN, n = 11). c and d Effects of a microinfusion of ALLN into the dorsal hippocampus immediately after the training on STM in female (c) or male (d) mice (c: VEH, n = 11; ALLN, n = 10; d: VEH, n = 10; ALLN, n = 10). *p < 0.05, compared with the VEH group at the test. Error bars indicate standerd error of mean (SEM)

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