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Fig. 3 | Molecular Brain

Fig. 3

From: Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction

Fig. 3

Decreased expression of GHSR in isogenic PARK2-KIKO iPSC-derived DA neurons. a Generation of isogenic PARK2-KIKO iPSCs. Schematic illustration of the gene-editing strategy for knock-in of the stop codon and the puromycin resistance gene into control iPSCs (201B7). b Double-labeling for the DA neuron marker tyrosine hydroxylase (TH, red) and the neuronal marker β-tubulin III (TUJ1, green) of control and PARK2-KIKO iPSC-derived dopaminergic neurons. c Expression level of Parkin mRNA in differentiated DA neurons derived from the control and PARK2−KIKO iPSC groups. **p < 0.01 vs. control. d-e The expression levels of GHSR1a (d) and GHSR1b (e) in differentiated dopaminergic neurons derived from the control and PARK2-KIKO iPSC groups. *p < 0.05 vs. control

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Molecular Brain

ISSN: 1756-6606