Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

Table 3 Cerebral infarct. Percentage of total cerebral volume

Treatment	Dose	N	Mean of total infarct volume (%)	SE (%)	Reduction in total infarct volume (%)	P
Saline	–	19	18.24	1.393	–	–
JNKD	1000	7	13.63	2.843	25.27	0.073
R18	30	10	11.34	1.401	37.82	0.002
	100	10	11.93	1.924	34.59	0.004
	300	8	11.78	1.921	35.42	0.007
	1000	11	10.25	2.082	43.80	< 0.001
R18D	30	9	13.51	2.058	25.93	0.038
	100	9	10.33	0.874	43.36	< 0.001
	300	9	12.07	1.540	33.82	0.007
	1000	8	11.83	0.957	35.14	0.007

N number of animals, SE standard error of mean, P calculated compared to saline vehicle control. All doses are in nmol/kg. Mean and SE expressed as percentage of total cerebral volume. JNKD = JNKI-1-TATD. Percentage reduction is mean percentage reduction compared to saline. All values P < 0.05 are in bold

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