Fig. 1

Scatter plots of the amplitudes of the startle response to a 110-dB pulse stimulus and percentages of prepulse inhibition of the acoustic startle response in male C57BL/6J mice. Relationships between acoustic startle responses to 110-dB pulse stimulus and percentages of prepulse inhibition were assessed by Spearman’s rank correlation coefficients (Rho) and p values at 74 dB prepulse + 110 dB stimulus trial (74–110 dB) and 78 dB prepulse + 110 dB stimulus trial (78–110 dB) in 1363 mice (a, e­). The mice were divided into low (b, f), intermediate (c, g), and high (d, h) startle responder groups on the basis of their startle amplitudes. In each responder group, relationships between the acoustic startle response and percentages of prepulse inhibition were assessed by calculating the correlation coefficients (Rho) and p values for 74–110 dB trials (b–d) and 78–110 dB trials (f–h)