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Table 3 Effect of NMDA treatment on number of ER cisternal stacks in neuronal somas in slice cultures (exp 1–2) as well as in dissociated cultures (exp 3–5), expressed as number per 100 neuronal somas

From: Stimulation-induced structural changes at the nucleus, endoplasmic reticulum and mitochondria of hippocampal neurons

Slice exp

Cont

30″ NMDA

1′ NMDA

2′ NMDA

3′ NMDA

 1

0 (17)

0 (20)

6 (16)

461 (18)

 

 2

0 (20)

5 (20)

55 (20)

289 (18)

688 (17)

 Mean ± SEM

0

2.5 ± 2.5

31 ± 25

375 ± 86

 

Cells exp

Cont

  

2′ NMDA

 

 3

0 (20)

  

25 (20)

 

 4

0 (20)

  

0 (20)

 

 5

0 (16)

  

10 (20)

 

 Mean ± SEM

0

  

12 ± 7

 
  1. Statistical analysis by ANOVA with Tukey’s post-test:
  2. For slice culture experiments, 3′ NMDA is highly significant over other conditions (P < 0.0001 vs. cont, 30″NMDA, 1′NMDA; P < 0.005 vs. 2′ NMDA). 2′ NMDA is highly significant over other conditions (P < 0.0001 vs. cont; P < 0.0005 vs. 30′ NMDA, 1′ NMDA). Not significant among all other multiple comparisons including cont, 30″ NMDA and 1′ NMDA
  3. For dissociated cell culture experiments, not significant between control and 2′NMDA
  4. (n) number of somas examined
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Molecular Brain

ISSN: 1756-6606