Fig. 1
From: Elevated contextual fear memory by SIRT6 depletion in excitatory neurons of mouse forebrain
Sirtuin 6 (SIRT6) genetic inactivation in excitatory forebrain neurons enhances contextual fear memory without affecting spatial memory, anxiety and locomotion in mice. a Fractions of time spent freezing (freezing levels) before and 1 day after conditioning in a contextual fear conditioning test (n = 20 for WT mice, and n = 19 for SIRT6 cKO mice). b Left, latency to find the platform in a Morris water maze during the training period. Middle, Proportions of time spent in each quadrant in a probe test 1 day after training. Right, proportions of time spent in each quadrant in a probe test 28 days after training (n = 8 per group). c Time spent in the open segments of an elevated zero maze, a measure of anxiety (n = 8 per group). d Left, time spent in the center of the open field box, another measure of anxiety. Right, distance traveled in each 5-min interval during the open field test (n = 8 per group). All graphs show means ± SEM. *, P < 0.05 (Student’s t-test)