Fig. 3
From: Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
Fmr1 KO mice decreased high-frequency stimulation-dependent summations of KAR mediated EPSCs in insular cortex neurons. a, b, Representative traces of KA EPSCs recorded by different numbers of stimulations (1, 5, 10, and 20 shocks; a-d, respectively) at the frequency of 200 Hz in Fmr1 WT (A) and Fmr1 KO mice (B). c, Insular cortex neurons in Fmr1 KO mice show strong reductions by these repetitive stimulations (n = 12 in 7 Fmr1 WT mice, n = 12 in 8 Fmr1 WT mice, *P < 0.05). d, KARs mediated input-output relationships for single shock-induced KAR-EPSCs showing intensity dependent summation in Fmr1 WT (A) and Fmr1 KO mice (B). e, Neurons in Fmr1 WT mice showed increased amplitudes of KAR-EPSCs that were intensity dependent (n = 9 in 7 Fmr1 WT mice), but neurons in Fmr1 KO mice showed no such significant increase (n = 7 in 5 Fmr1 KO mice, *P < 0.05)